Does Amphetamine Interact with Ritonavir?
CDI records a major classification for Amphetamine and Ritonavir. The stored summary is: CYP2D6 inhibitor that increases amphetamine exposure and risk of serotonin syndrome. The mechanism involves cyp2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Amphetamine Class
- Central Nervous System Stimulant
- Ritonavir Class
- Cytochrome P450 3A Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP2D6 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Amphetamine and your doctor is considering prescribing Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider