Does Mao Inhibitors Interact with Amphetamine?
CDI records a contraindicated classification for Mao Inhibitors and Amphetamine. The stored summary is: MAOI antidepressants slow amphetamine metabolism, increasing effects on norepinephrine release causing hypertensive crisis. Toxic neurological effects and malignant hyperpyrexia can occur with fatal results. The mechanism involves decreased amphetamine metabolism via mao inhibition, increased monoamine release. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Amphetamine Class
- Central Nervous System Stimulant
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased amphetamine metabolism via MAO inhibition, increased monoamine release
What To Tell Your Doctor or Pharmacist
If you are taking Mao Inhibitors and your doctor is considering prescribing Amphetamine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider