Does Amphetamine Extended Release Interact with Alkalinizing Agents?
Amphetamine Extended Release and Alkalinizing Agents have a major drug interaction according to U.S. FDA drug labeling data. Increase blood levels and potentiate the action of amphetamine. Co-administration should be avoided. The mechanism involves alkalinizing agents increase amphetamine blood levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Amphetamine Extended Release Class
- Central Nervous System Stimulant
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Amphetamine Extended Release and Alkalinizing Agents occurs because alkalinizing agents increase amphetamine blood levels. Clinically, this means increase blood levels and potentiate the action of amphetamine. co-administration should be avoided. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Amphetamine Extended Release and your doctor is considering prescribing Alkalinizing Agents (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider