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Does Amphotericin B Interact with Cidofovir?

CDI records a contraindicated classification for Amphotericin B and Cidofovir. The stored summary is: Concomitant administration is contraindicated due to nephrotoxic potential. Must be discontinued at least 7 days prior to cidofovir therapy. The mechanism involves nephrotoxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Contraindicated
Amphotericin B Class: Lipid-based Polyene Antifungal
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

Nephrotoxicity

What To Tell Your Doctor or Pharmacist

If you are taking Amphotericin B and your doctor is considering prescribing Cidofovir (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Amphotericin B(AmBisome)+💊 Cidofovir

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

CDI classifies this record as contraindicated. Confirm the applicable product labeling with your prescriber or pharmacist.

Severity scale

MinorContra

On record

Yes

Drug A class

Lipid-based Polyene Antifungal

Drug B class

—

Source

NLP:cidofovir dihydrate

What this means in plain English

Concomitant administration is contraindicated due to nephrotoxic potential. Must be discontinued at least 7 days prior to cidofovir therapy.

About Amphotericin B and Cidofovir

Amphotericin B is a Lipid-based Polyene Antifungal. Amphotericin B is also sold under the brand name AmBisome. Both Amphotericin B and Cidofovir carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:cidofovir dihydrate

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.