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Does Anakinra Interact with Candesartan Cilexetil?

Anakinra and Candesartan Cilexetil have a major drug interaction according to U.S. FDA drug labeling data. Triple combination with candesartan cilexetil and an ACE-inhibitor is generally not recommended due to increased risks of hypotension, hyperkalemia, and renal dysfunction. The mechanism involves triple blockade of renin-angiotensin system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Anakinra Class
Interleukin-1 Receptor Antagonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Anakinra and Candesartan Cilexetil occurs because triple blockade of renin-angiotensin system. Clinically, this means triple combination with candesartan cilexetil and an ace-inhibitor is generally not recommended due to increased risks of hypotension, hyperkalemia, and renal dysfunction. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Anakinra and your doctor is considering prescribing Candesartan Cilexetil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Anakinra(Kineret)+💊 Candesartan Cilexetil(Candesartan Cilexetil)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Interleukin-1 Receptor Antagonist
Drug B class
—
Source
NLP:candesartan cilexetil

What this means in plain English

Triple combination with candesartan cilexetil and an ACE-inhibitor is generally not recommended due to increased risks of hypotension, hyperkalemia, and renal dysfunction.

What the FDA label says

"Triple blockade of renin-angiotensin system"

📖 Source: NLP:candesartan cilexetil

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.