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Does Anakinra Interact with Infliximab Dyyb?

Anakinra and Infliximab Dyyb have a contraindicated drug interaction according to U.S. FDA drug labeling data. Combination with anakinra is not recommended due to increased risk of serious infections with no added clinical benefit seen in clinical studies of TNF blockers. The mechanism involves increased immunosuppression leading to serious infections. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Anakinra Class
Interleukin-1 Receptor Antagonist
Infliximab Dyyb Class
Tumor Necrosis Factor Blocker
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Anakinra and Infliximab Dyyb occurs because increased immunosuppression leading to serious infections. Clinically, this means combination with anakinra is not recommended due to increased risk of serious infections with no added clinical benefit seen in clinical studies of tnf blockers. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Anakinra and your doctor is considering prescribing Infliximab Dyyb (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Anakinra(Kineret)+💊 Infliximab Dyyb(Inflectra)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Interleukin-1 Receptor Antagonist
Drug B class
Tumor Necrosis Factor Blocker
Source
NLP:infliximab-dyyb

What this means in plain English

Combination with anakinra is not recommended due to increased risk of serious infections with no added clinical benefit seen in clinical studies of TNF blockers.

What the FDA label says

"Increased immunosuppression leading to serious infections"

📖 Source: NLP:infliximab-dyyb

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.