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Does Antacids Containing Magnesium Interact with Levofloxacin In 5 Dextrose?

Antacids Containing Magnesium and Levofloxacin In 5 Dextrose have a contraindicated drug interaction according to U.S. FDA drug labeling data. Do not co-administer intravenous levofloxacin in the same IV line with magnesium or other multivalent cations due to chelation risk. The mechanism involves chelation of multivalent cations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Levofloxacin In 5 Dextrose Class
Fluoroquinolone Antibacterial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Antacids Containing Magnesium and Levofloxacin In 5 Dextrose occurs because chelation of multivalent cations. Clinically, this means do not co-administer intravenous levofloxacin in the same iv line with magnesium or other multivalent cations due to chelation risk. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Antacids Containing Magnesium and your doctor is considering prescribing Levofloxacin In 5 Dextrose (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Antacids Containing Magnesium+💊 Levofloxacin In 5 Dextrose(Levofloxacin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Fluoroquinolone Antibacterial
Source
NLP:levofloxacin in 5% dextrose

What this means in plain English

Do not co-administer intravenous levofloxacin in the same IV line with magnesium or other multivalent cations due to chelation risk.

What the FDA label says

"Chelation of multivalent cations"

📖 Source: NLP:levofloxacin in 5% dextrose

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.