Home›Anti Fungal Agents That Are Cyp3a4 Substrates›Anti Fungal Agents That Are Cyp3a4 Substrates + Ivosidenib

Does Anti Fungal Agents That Are Cyp3a4 Substrates Interact with Ivosidenib?

Anti Fungal Agents That Are Cyp3a4 Substrates and Ivosidenib have a contraindicated drug interaction according to U.S. FDA drug labeling data. Ivosidenib induces CYP3A4, causing expected loss of antifungal efficacy. Do not administer concomitantly. The mechanism involves cyp3a4 induction decreases antifungal concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Ivosidenib Class
Isocitrate Dehydrogenase 1 Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Anti Fungal Agents That Are Cyp3a4 Substrates and Ivosidenib occurs because cyp3a4 induction decreases antifungal concentrations. Clinically, this means ivosidenib induces cyp3a4, causing expected loss of antifungal efficacy. do not administer concomitantly. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Anti Fungal Agents That Are Cyp3a4 Substrates and your doctor is considering prescribing Ivosidenib (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Anti Fungal Agents That Are Cyp3a4 Substrates(Inzo)+💊 Ivosidenib(Tibsovo)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Isocitrate Dehydrogenase 1 Inhibitor
Source
NLP:ivosidenib

What this means in plain English

Ivosidenib induces CYP3A4, causing expected loss of antifungal efficacy. Do not administer concomitantly.

About Anti Fungal Agents That Are Cyp3a4 Substrates and Ivosidenib

Ivosidenib is an Isocitrate Dehydrogenase 1 Inhibitor. You may recognize them by the brand names Inzo and Tibsovo. Ivosidenib is taken by mouth. Ivosidenib additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"CYP3A4 induction decreases antifungal concentrations"

📖 Source: NLP:ivosidenib

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Anti Fungal Agents That Are Cyp3a4 Substrates and Ivosidenib against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.