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Does Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H Interact with Warfarin?

Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and Warfarin have a major drug interaction according to U.S. FDA drug labeling data. Vitamin K antagonizes the anticoagulant action of warfarin, requiring prothrombin/INR monitoring and potential dose adjustment. The mechanism involves vitamin k antagonizes warfarin anticoagulant effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Major
Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H Class: Vitamin C
Management: Close medical supervision required
Data Source: U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and Warfarin occurs because vitamin k antagonizes warfarin anticoagulant effect. Clinically, this means vitamin k antagonizes the anticoagulant action of warfarin, requiring prothrombin/inr monitoring and potential dose adjustment. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and your doctor is considering prescribing Warfarin (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask how frequently you should be monitored while these are co-prescribed
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H(Pediatric Infuvite Multiple Vitamins)+💊 Warfarin(Warfarin Sodium)

Severity & Interaction Details

⚠️

major

Use with caution — major interaction

Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.

Severity scale

MinorContra

On record

Yes

Drug A class

Vitamin C

Drug B class

—

Source

NLP:ascorbic acid, vitamin a palmitate, cholecalciferol, thiamine hydrochloride, riboflavin-5 phosphate sodium, pyridoxine hydrochloride, niacinamide, dexpanthenol, alpha-tocopherol acetate, vitamin k1, folic acid, biotin, cyanocobalamin

What this means in plain English

Vitamin K antagonizes the anticoagulant action of warfarin, requiring prothrombin/INR monitoring and potential dose adjustment.

About Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and Warfarin

Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H is a Vitamin C. Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H is given by intravenous (IV) infusion, whereas Warfarin is taken by mouth. Warfarin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Vitamin K antagonizes warfarin anticoagulant effect"

📖 Source: NLP:ascorbic acid, vitamin a palmitate, cholecalciferol, thiamine hydrochloride, riboflavin-5 phosphate sodium, pyridoxine hydrochloride, niacinamide, dexpanthenol, alpha-tocopherol acetate, vitamin k1, folic acid, biotin, cyanocobalamin

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Semaglutide-Glycine-Cyanocobalamin Injectable, 2.5 mg, 5 mg, 1 MG/ML, 0.5 mL vials, Rx only, Northweabout Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H · 2026-04

FDA

FDA Safety Alert: Warfarin Sodium Tablets, USP, 5 mg, 100 Tablets per bottle, Rx Only, Manufactured for: Teva Pharmaceabout Warfarin · 2024-01

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.