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Does Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H Interact with Warfarin?

Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and Warfarin have a major drug interaction according to U.S. FDA drug labeling data. Vitamin K antagonizes the anticoagulant action of warfarin, requiring prothrombin/INR monitoring and potential dose adjustment. The mechanism involves vitamin k antagonizes warfarin anticoagulant effect. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H Class
Vitamin C
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and Warfarin occurs because vitamin k antagonizes warfarin anticoagulant effect. Clinically, this means vitamin k antagonizes the anticoagulant action of warfarin, requiring prothrombin/inr monitoring and potential dose adjustment. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H and your doctor is considering prescribing Warfarin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ascorbic Acid Vitamin A Palmitate Cholecalciferol Thiamine H(Pediatric Infuvite Multiple Vitamins)+💊 Warfarin(Warfarin Sodium)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Vitamin C
Drug B class
—
Source
NLP:ascorbic acid, vitamin a palmitate, cholecalciferol, thiamine hydrochloride, riboflavin-5 phosphate sodium, pyridoxine hydrochloride, niacinamide, dexpanthenol, alpha-tocopherol acetate, vitamin k1, folic acid, biotin, cyanocobalamin

What this means in plain English

Vitamin K antagonizes the anticoagulant action of warfarin, requiring prothrombin/INR monitoring and potential dose adjustment.

What the FDA label says

"Vitamin K antagonizes warfarin anticoagulant effect"

📖 Source: NLP:ascorbic acid, vitamin a palmitate, cholecalciferol, thiamine hydrochloride, riboflavin-5 phosphate sodium, pyridoxine hydrochloride, niacinamide, dexpanthenol, alpha-tocopherol acetate, vitamin k1, folic acid, biotin, cyanocobalamin

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.