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Does Aspirin And Dipyridamole Interact with Methotrexate?

Aspirin And Dipyridamole and Methotrexate have a major drug interaction according to U.S. FDA drug labeling data. Salicylate inhibits renal clearance of methotrexate, leading to bone marrow toxicity, especially in elderly or renal impaired patients. The mechanism involves salicylate inhibits renal clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Aspirin And Dipyridamole Class
Nonsteroidal Anti-inflammatory Drug
Methotrexate Class
Folate Analog Metabolic Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Aspirin And Dipyridamole and Methotrexate occurs because salicylate inhibits renal clearance. Clinically, this means salicylate inhibits renal clearance of methotrexate, leading to bone marrow toxicity, especially in elderly or renal impaired patients. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Aspirin And Dipyridamole and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aspirin And Dipyridamole(Aspirin And Dipyridamole)+💊 Methotrexate(Methotrexate)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug
Drug B class
Folate Analog Metabolic Inhibitor
Source
NLP:aspirin and dipyridamole

What this means in plain English

Salicylate inhibits renal clearance of methotrexate, leading to bone marrow toxicity, especially in elderly or renal impaired patients.

What the FDA label says

"Salicylate inhibits renal clearance"

📖 Source: NLP:aspirin and dipyridamole

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.