Does Aspirin And Extended Release Dipyridamole Interact with Nonselective Beta Adrenergic Antagonists?
Aspirin And Extended Release Dipyridamole and Nonselective Beta Adrenergic Antagonists have a moderate drug interaction according to U.S. FDA drug labeling data. Aspirin may diminish the hypotensive effects of beta blockers due to inhibition of renal prostaglandins, leading to decreased renal blood flow and salt/fluid retention. The mechanism involves inhibition of renal prostaglandins. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Aspirin And Extended Release Dipyridamole Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Aspirin And Extended Release Dipyridamole and Nonselective Beta Adrenergic Antagonists occurs because inhibition of renal prostaglandins. Clinically, this means aspirin may diminish the hypotensive effects of beta blockers due to inhibition of renal prostaglandins, leading to decreased renal blood flow and salt/fluid retention. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Aspirin And Extended Release Dipyridamole and your doctor is considering prescribing Nonselective Beta Adrenergic Antagonists (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider