Nonselective Beta-Adrenergic Antagonists Interactions

Bisoprolol fumarate should not be combined with other beta-blocking agents.

Source: NLP:bisoprolol fumarate

Should not be combined with other beta-blocking agents due to additive effects.

Source: NLP:bisoprolol fumarate and hydrochlorothiazide

Labetalol antagonizes the bronchodilatory effect of beta-receptor agonist drugs and is contraindicated in patients with bronchial asthma.

Source: NLP:labetalol hydrochloride

May block bronchodilatory effects and produce severe bronchospasm in asthmatic patients. Patients with asthma should not normally be treated with beta-blockers.

Source: NLP:levalbuterol

May decrease effectiveness of albuterol sulfate and produce severe bronchospasm. Patients with asthma should not normally be treated with beta-blockers.

Source: NLP:albuterol sulfate

May decrease effectiveness of albuterol and produce severe bronchospasm in asthma patients. Use cardioselective beta-blockers with caution when necessary.

Source: NLP:albuterol sulfate and budesonide

Negative chronotrope. Potentiates electrophysiologic and hemodynamic effects resulting in bradycardia, sinus arrest, and AV block.

Source: NLP:amiodarone hydrochloride

May produce severe, prolonged hypertension when combined with local anesthetic solutions containing epinephrine.

Source: NLP:articaine hydrochloride and epinephrine

May produce severe, prolonged hypertension when local anesthetic solutions containing epinephrine are administered to patients receiving these agents.

Source: NLP:articaine hydrochloride, epinephrine bitartrate

May cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Source: NLP:betamethasone sodium phosphate and betamethasone acetate, bupivacaine hydrochloride, povidine iodine

Concomitant use may potentiate systemic beta-blockade with additive effects on both systemic and intraocular pressure.

Source: NLP:brimonidine tartrate and timolol maleate

May block bronchodilatory effects of formoterol and produce severe bronchospasm in asthma patients. Use with extreme caution; avoid in asthma.

Source: NLP:budesonide and formoterol fumarate

May cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Source: NLP:bupivacaine hydrochloride

May cause severe hypertension and bradycardia. Concurrent use should generally be avoided; if necessary, careful monitoring of blood pressure and heart rate is essential.

Source: NLP:bupivacaine hydrochloride and epinephrine bitartrate

Potentiate bradycardia and risk of AV block. Caution is warranted.

Source: NLP:clonidine hydrochloride

Administration with Bupivacaine Hydrochloride and Epinephrine may cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Source: NLP:dexamethasone sodium phosphate, bupivacaine hydrochloride, povidine iodine

Additive effects in prolonging AV conduction; concomitant use usually well tolerated but may cause problems in patients with left ventricular dysfunction or cardiac conduction abnormalities.

Source: NLP:diltiazem hydrochloride

Oral beta-blockers with dorzolamide/timolol may produce additive systemic beta-blockade effects. Concomitant topical beta-blockers not recommended.

Source: NLP:dorzolamide hydrochloride and timolol maleate

Limited experience; concomitant use during fingolimod initiation may cause severe bradycardia or heart block due to additive heart rate reduction.

Source: NLP:fingolimod

Drugs that slow heart rate. Concomitant use during fingolimod initiation may cause severe bradycardia or heart block. Consider switching to alternative drugs.

Source: NLP:fingolimod hcl

May block bronchodilatory effects of salmeterol and produce severe bronchospasm.

Source: NLP:fluticasone propionate and salmeterol xinafoate

May inhibit therapeutic effects of formoterol and cause severe bronchospasm in COPD patients. Use only when medically necessary and with caution.

Source: NLP:formoterol fumarate

May block bronchodilatory effects of formoterol and produce severe bronchospasm. Use with caution; avoid in asthma patients.

Source: NLP:budesonide and formoterol fumarate dihydrate

Beta-blockers lower the threshold for contrast reactions, increase severity of reactions, and reduce responsiveness to epinephrine treatment. Use caution when administering iodixanol to patients taking beta-blockers.

Source: NLP:iodixanol

Beta-blockers block pulmonary effects of levalbuterol and may produce severe bronchospasm in asthmatic patients. Patients with asthma should not normally be treated with beta-blockers.

Source: NLP:levalbuterol hydrochloride

May block bronchodilatory effects of levalbuterol and produce severe bronchospasm. Patients with asthma should not normally be treated with beta-blockers.

Source: NLP:levalbuterol tartrate

Administration of lidocaine solutions containing epinephrine may cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Source: NLP:lidocaine hydrochloride

May cause severe hypertension and bradycardia with possible heart block. Concurrent use should generally be avoided.

Source: NLP:lidocaine hydrochloride and epinephrine

Administration of Bupivacaine Hydrochloride and Epinephrine in patients receiving nonselective beta-adrenergic antagonists may cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Source: NLP:methylprednisolone acetate, lidocaine hydrochloride, bupivacaine hydrochloride, povidine iodine, isopropyl alcohol

May decrease effectiveness of formoterol and produce severe bronchospasm. Use with caution only when medically necessary.

Source: NLP:mometasone furoate and formoterol fumarate dihydrate

Combination may increase likelihood of congestive heart failure, severe hypotension, or exacerbation of angina, though usually well tolerated.

Source: NLP:nifedipine

Probenecid elevates plasma concentrations of beta-lactams, increasing incidence of adverse reactions including psychic disturbances.

Source: NLP:probenecid

Probenecid elevates plasma concentrations of beta-lactams, increasing incidence of adverse reactions including psychic disturbances.

Source: NLP:probenecid and colchicine

Beta-blockers block the pulmonary effect of terbutaline and may produce severe bronchospasm in asthmatic patients.

Source: NLP:terbutaline sulfate

Beta-blockers may decrease effectiveness of olodaterol and produce severe bronchospasm in COPD patients. Use with caution and only when medically necessary.

Source: NLP:tiotropium bromide and olodaterol

May block bronchodilatory effects of vilanterol and produce severe bronchospasm in COPD patients. Avoid use; if necessary, use cardioselective beta-blockers with caution.

Source: NLP:umeclidinium bromide and vilanterol trifenatate

Serious adverse effects reported in rare instances with intravenous beta-blockers and intravenous verapamil, especially in severe cardiomyopathy, heart failure, or recent MI. May result in exaggerated hypotensive response.

Source: NLP:verapamil hydrochloride

Given with adenosine without apparent adverse interactions, but adenosine should be used with caution due to potential additive depressant effects on SA and AV nodes.

Source: NLP:adenosine

Caution advised due to potential additive hypotensive and pulse-reducing effects.

Source: NLP:apraclonidine

May decrease effectiveness and block bronchodilatory effects of arformoterol. Use with caution and only when medically necessary.

Source: NLP:arformoterol tartrate

Aspirin may diminish the hypotensive effects of beta blockers through inhibition of renal prostaglandins.

Source: NLP:aspirin and dipyridamole

Aspirin may diminish the hypotensive effects of beta blockers due to inhibition of renal prostaglandins, leading to decreased renal blood flow and salt/fluid retention.

Source: NLP:aspirin and extended-release dipyridamole

Alpha-2 agonists may reduce blood pressure; caution advised when using beta-blockers concurrently.

Source: NLP:brimonidine

Alpha-2 agonists may reduce blood pressure; caution advised when used with beta-blockers due to potential additive hypotensive effects.

Source: NLP:brimonidine tartrate

Additive effects on systemic beta-blockade when used orally with carteolol hydrochloride ophthalmic solution. Close observation recommended.

Source: NLP:carteolol hydrochloride

Concomitant use may diminish the antihypertensive effect. Monitor blood pressure.

Source: NLP:celecoxib

Cevimeline should be administered with caution due to the possibility of conduction disturbances when used concurrently with beta adrenergic antagonists.

Source: NLP:cevimeline hydrochloride

Monitor heart rate in patients receiving clonidine concomitantly with beta-blockers, which affect sinus node function or AV nodal conduction.

Source: NLP:clonidine

Monitor heart rate in patients receiving clonidine concomitantly with beta-blockers due to effects on sinus node function or AV nodal conduction.

Source: NLP:clonidine transdermal system

Concomitant use requires adequate hydration and renal function assessment at beginning of treatment.

Source: NLP:diclofenac

May diminish antihypertensive effect. Monitor blood pressure.

Source: NLP:diclofenac sodium

When administered concomitantly, patients should be adequately hydrated and renal function assessed at baseline.

Source: NLP:diclofenac sodium, methyl salicylate

NSAIDs may diminish the antihypertensive effect of beta-blockers including propranolol.

Source: NLP:diclofenac sodium, kinesiology tape

May potentiate hypoglycemic action of glyburide; patient should be closely observed for hypoglycemia.

Source: NLP:glyburide

May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglycemia.

Source: NLP:glimepiride

Beta blockers may potentiate hypoglycemic action of glipizide. Patient should be observed closely for hypoglycemia when initiated or withdrawn.

Source: NLP:glipizide

Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given glucagon. The increase may require therapy in patients with coronary artery disease.

Source: NLP:glucagon

May potentiate hypoglycemic action of glyburide; monitor closely for hypoglycemia.

Source: NLP:glyburide and metformin hydrochloride

May potentiate hypoglycemic action of glyburide; monitor for hypoglycemia.

Source: NLP:glyburide-metformin hydrochloride

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Increased glucose monitoring may be required.

Source: NLP:insulin aspart

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Increased glucose monitoring required.

Source: NLP:insulin aspart-szjj

May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and increased glucose monitoring may be required.

Source: NLP:insulin degludec

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dosage adjustment and increased glucose monitoring required.

Source: NLP:insulin glargine

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Source: NLP:insulin glulisine

May increase or decrease blood glucose effect and blunt signs/symptoms of hypoglycemia; increased glucose monitoring required.

Source: NLP:insulin human

May increase or decrease blood glucose lowering effect and may blunt signs and symptoms of hypoglycemia. Increased glucose monitoring required.

Source: NLP:insulin lispro

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Source: NLP:insulin lispro-aabc

Beta blockers may exaggerate cardiovascular effects of isoflurane, including hypotension and negative inotropic effects.

Source: NLP:isoflurane

Negative chronotropes that increase risk of bradycardia with ivabradine. Monitor heart rate.

Source: NLP:ivabradine

Labetalol can blunt the bronchodilator effect of beta-agonists in patients with bronchospasm; higher than normal anti-asthmatic doses may be required.

Source: NLP:labetalol

Lacosamide should be used with caution with beta-blockers due to risk of AV block, bradycardia, or ventricular tachyarrhythmia. ECG monitoring recommended.

Source: NLP:lacosamide

Use with caution due to risk of AV block, bradycardia, or ventricular tachyarrhythmia. ECG monitoring before initiation and after titration is recommended.

Source: NLP:lacosamide oral solution

Lanreotide may have additive effects with bradycardia-inducing drugs, reducing heart rate; dosage adjustment may be necessary.

Source: NLP:lanreotide acetate

Concomitant use with meloxicam may diminish the antihypertensive effect of beta-blockers. Monitor blood pressure.

Source: NLP:meloxicam

Hyperthyroidism increases clearance of beta blockers with high extraction ratio. Dose reduction may be needed when patient becomes euthyroid with methimazole treatment.

Source: NLP:methimazole

Concomitant administration may enhance the vasoconstrictive action of ergot alkaloids; caution should be exercised.

Source: NLP:methylergonovine maleate

NSAIDs may diminish the antihypertensive effect of beta-blockers.

Source: NLP:naproxen

Concomitant use can potentiate electrophysiologic and hemodynamic effects, resulting in bradycardia, sinus arrest, and AV block.

Source: NLP:nexterone (amiodarone hci)

Beta-receptor blockers have been frequently administered concomitantly with nicardipine hydrochloride. The combination is well tolerated.

Source: NLP:nicardipine hydrochloride

Blunt reflex tachycardia without preventing hypotensive effects. Possible additive hypotensive effects; additional hypotension may occur in angina patients.

Source: NLP:nitroglycerin

May cause additional hypotensive effects when used with nitroglycerin. Beta-blockers blunt reflex tachycardia without preventing hypotensive effects.

Source: NLP:nitroglycerin lingual

Concomitant administration of beta-blockers may have an additive effect on reduction of heart rate associated with octreotide.

Source: NLP:octreotide acetate

Alpha-adrenergic agonists may impact blood pressure; caution advised when used with beta-blockers.

Source: NLP:oxymetazoline hydrochloride

Pilocarpine should be administered with caution due to possibility of conduction disturbances.

Source: NLP:pilocarpine hydrchloride

Pilocarpine should be administered with caution due to possibility of conduction disturbances.

Source: NLP:pilocarpine hydrochloride

May produce unfavorable interactions with potassium supplements, risk of hyperkalemia.

Source: NLP:potassium bicarbonate

Hyperthyroidism increases clearance of beta blockers. A reduced dose may be needed when hyperthyroid patients become euthyroid with propylthiouracil treatment.

Source: NLP:propylthiouracil

Concomitant use may potentiate systemic beta-blockade with additive effects on heart rate and intraocular pressure.

Source: NLP:timolol hemihydrate

Potential additive effects of beta-blockade, both systemic and on intraocular pressure. Concomitant use of two topical beta-adrenergic blocking agents is not recommended.

Source: NLP:timolol maleate

Concomitant use of two topical beta-adrenergic blocking agents is not recommended. Patients receiving oral beta-blockers with timolol should be observed for additive effects of beta-blockade.

Source: NLP:timolol maleate ophthalmic gel forming solution 0.25%

Compounds that quench active oxygen species or scavenge radicals would be expected to decrease VISUDYNE activity.

Source: NLP:verteporfin for injection

Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.

Source: NLP:enalapril maleate

Enalapril has been used concomitantly without evidence of clinically significant adverse interactions.

Source: NLP:enalapril maleate and hydrochlorothiazide