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Does Atazanavir Interact with Dapagliflozin And Saxagliptin?

Atazanavir and Dapagliflozin And Saxagliptin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Anticipated significant increase in saxagliptin plasma concentrations. Do not coadminister with dapagliflozin and saxagliptin. The mechanism involves strong cyp3a4/5 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Dapagliflozin And Saxagliptin Class
Sodium-Glucose Cotransporter 2 Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Atazanavir and Dapagliflozin And Saxagliptin occurs because strong cyp3a4/5 inhibition. Clinically, this means anticipated significant increase in saxagliptin plasma concentrations. do not coadminister with dapagliflozin and saxagliptin. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Atazanavir and your doctor is considering prescribing Dapagliflozin And Saxagliptin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Atazanavir+💊 Dapagliflozin And Saxagliptin(Dapagliflozin And Saxagliptin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Sodium-Glucose Cotransporter 2 Inhibitor
Source
NLP:dapagliflozin and saxagliptin

What this means in plain English

Anticipated significant increase in saxagliptin plasma concentrations. Do not coadminister with dapagliflozin and saxagliptin.

What the FDA label says

"Strong CYP3A4/5 inhibition"

📖 Source: NLP:dapagliflozin and saxagliptin

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.