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Does Atazanavir Interact with Esomeprazole Magnesium Delayed Release Capsules?

Atazanavir and Esomeprazole Magnesium Delayed Release Capsules have a contraindicated drug interaction according to U.S. FDA drug labeling data. Esomeprazole magnesium substantially decreases atazanavir plasma concentrations (AUC decreased by 94%), which may result in loss of therapeutic effect and development of drug resistance. The mechanism involves increased gastric ph and possible cyp2c19 inhibition affecting absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Atazanavir and Esomeprazole Magnesium Delayed Release Capsules occurs because increased gastric ph and possible cyp2c19 inhibition affecting absorption. Clinically, this means esomeprazole magnesium substantially decreases atazanavir plasma concentrations (auc decreased by 94%), which may result in loss of therapeutic effect and development of drug resistance. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Atazanavir and your doctor is considering prescribing Esomeprazole Magnesium Delayed Release Capsules (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Atazanavir+💊 Esomeprazole Magnesium Delayed Release Capsules(Esomeprazole Magnesium)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:esomeprazole magnesium delayed release capsules

What this means in plain English

Esomeprazole magnesium substantially decreases atazanavir plasma concentrations (AUC decreased by 94%), which may result in loss of therapeutic effect and development of drug resistance.

What the FDA label says

"Increased gastric pH and possible CYP2C19 inhibition affecting absorption"

📖 Source: NLP:esomeprazole magnesium delayed release capsules

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.