Does Atazanavir Interact with Esomeprazole Magnesium Delayed Release Capsules?
CDI records a contraindicated classification for Atazanavir and Esomeprazole Magnesium Delayed Release Capsules. The stored summary is: Esomeprazole magnesium substantially decreases atazanavir plasma concentrations (AUC decreased by 94%), which may result in loss of therapeutic effect and development of drug resistance. The mechanism involves increased gastric ph and possible cyp2c19 inhibition affecting absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased gastric pH and possible CYP2C19 inhibition affecting absorption
What To Tell Your Doctor or Pharmacist
If you are taking Atazanavir and your doctor is considering prescribing Esomeprazole Magnesium Delayed Release Capsules (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider