Does Atazanavir Interact with Nevirapine?
CDI records a contraindicated classification for Atazanavir and Nevirapine. The stored summary is: Nevirapine substantially decreases atazanavir exposure and increases nevirapine exposures. Do not co-administer. The mechanism involves nevirapine induces metabolism of atazanavir via cyp3a and 2b6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Nevirapine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Nevirapine induces metabolism of atazanavir via CYP3A and 2B6
What To Tell Your Doctor or Pharmacist
If you are taking Atazanavir and your doctor is considering prescribing Nevirapine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider