Does Atenolol Interact with Disopyramide?
Atenolol and Disopyramide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Associated with severe bradycardia, asystole, and heart failure when administered with beta-blockers. The mechanism involves potent negative inotropic and chronotropic effects additive to beta-blocker effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Atenolol Class
- beta-Adrenergic Blocker
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Atenolol and Disopyramide occurs because potent negative inotropic and chronotropic effects additive to beta-blocker effects. Clinically, this means associated with severe bradycardia, asystole, and heart failure when administered with beta-blockers. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Atenolol and your doctor is considering prescribing Disopyramide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider