Does Atenolol Interact with Disopyramide?
CDI records a contraindicated classification for Atenolol and Disopyramide. The stored summary is: Associated with severe bradycardia, asystole, and heart failure when administered with beta-blockers. The mechanism involves potent negative inotropic and chronotropic effects additive to beta-blocker effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Atenolol Class
- beta-Adrenergic Blocker
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Potent negative inotropic and chronotropic effects additive to beta-blocker effects
What To Tell Your Doctor or Pharmacist
If you are taking Atenolol and your doctor is considering prescribing Disopyramide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider