Does Atogepant Interact with Rifampin?
Atogepant and Rifampin have a moderate drug interaction according to U.S. FDA drug labeling data. Strong CYP3A4 inducer and OATP1B1/OATP1B3 inhibitor resulting in significant decrease in atogepant exposure; dosage adjustment and monitoring for reduced efficacy recommended. The mechanism involves cyp3a4 induction and oatp inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Atogepant Class
- Calcitonin Gene-related Peptide Receptor Antagonist
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Atogepant and Rifampin occurs because cyp3a4 induction and oatp inhibition. Clinically, this means strong cyp3a4 inducer and oatp1b1/oatp1b3 inhibitor resulting in significant decrease in atogepant exposure; dosage adjustment and monitoring for reduced efficacy recommended. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Atogepant and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider