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Does Azathioprine Interact with Ustekinumab Aauz?

Azathioprine and Ustekinumab Aauz have a moderate drug interaction according to U.S. FDA drug labeling data. Immunomodulator used concomitantly in approximately 30% of Crohn's disease and ulcerative colitis subjects. Use did not appear to influence overall safety or efficacy of ustekinumab. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Azathioprine Class
Purine Antimetabolite
Ustekinumab Aauz Class
Interleukin-12 Antagonist
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Azathioprine and your doctor is considering prescribing Ustekinumab Aauz (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Azathioprine(Imuran)+💊 Ustekinumab Aauz(Otulfi)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Purine Antimetabolite
Drug B class
Interleukin-12 Antagonist
Source
NLP:ustekinumab-aauz

What this means in plain English

Immunomodulator used concomitantly in approximately 30% of Crohn's disease and ulcerative colitis subjects. Use did not appear to influence overall safety or efficacy of ustekinumab.

About Azathioprine and Ustekinumab Aauz

Azathioprine is a Purine Antimetabolite, while Ustekinumab Aauz is an Interleukin-12 Antagonist. You may recognize them by the brand names Imuran and Otulfi. Azathioprine is taken by mouth, whereas Ustekinumab Aauz is given by injection under the skin. Azathioprine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.