Does Azithromycin Interact with Desloratadine?
The desloratadine label reports increased desloratadine and metabolite concentrations with azithromycin in controlled studies, but no clinically relevant changes in the safety profile.
Label evidence and limitations
Named-drug label evidence. The absence of a clinically relevant safety change in those studies is an essential qualification. An exposure change alone does not validate CDI’s moderate severity category or prove universal safety.
Product scope: Oral desloratadine tablets; controlled-study exposure finding.
Read the DailyMed label: These highlights do not include all the information needed to use DESLORATADINE TABLETS safely and effectively. See full prescribing information for DESLORATADINE TABLETS. DESLORATADINE tablets for oral use Initial U.S. Approval: 2001
Section: 7.1 Inhibitors of Cytochrome P450 3A4. Compared version 17, label date 2026-06-30. The linked label may be updated after this comparison.
The original record has no saved label identifier. This comparison uses a label located during the source check; it does not recover the original extraction source.
AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.
- Stored CDI classification
- Moderate
- Desloratadine Class
- Histamine-1 Receptor Antagonist
- Management
- Confirm exact products with your pharmacist
- Data Source
- Product label via NLM DailyMed
What To Tell Your Doctor or Pharmacist
If you are taking Azithromycin and your doctor is considering prescribing Desloratadine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider