Does Azithromycin Interact with Desloratadine And Pseudoephedrine Sulfate?
Azithromycin and Desloratadine And Pseudoephedrine Sulfate have a minor drug interaction according to U.S. FDA drug labeling data. Co-administration results in increased plasma concentrations of desloratadine but no clinically relevant changes in safety profile. The mechanism involves inhibition of cytochrome p450 3a4. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Desloratadine And Pseudoephedrine Sulfate Class
- Histamine-1 Receptor Antagonist
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Azithromycin and Desloratadine And Pseudoephedrine Sulfate occurs because inhibition of cytochrome p450 3a4. Clinically, this means co-administration results in increased plasma concentrations of desloratadine but no clinically relevant changes in safety profile. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Azithromycin and your doctor is considering prescribing Desloratadine And Pseudoephedrine Sulfate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider