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Does Benazepril Hydrochloride And Hydrochlorothiazide Interact with Lithium?

Benazepril Hydrochloride And Hydrochlorothiazide and Lithium have a major drug interaction according to U.S. FDA drug labeling data. Renal clearance of lithium is reduced by thiazides and ACE inhibitors, increasing risk of lithium toxicity. Monitor lithium levels. The mechanism involves reduced renal clearance by thiazides and ace inhibitors. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Benazepril Hydrochloride And Hydrochlorothiazide Class
Thiazide Diuretic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Benazepril Hydrochloride And Hydrochlorothiazide and Lithium occurs because reduced renal clearance by thiazides and ace inhibitors. Clinically, this means renal clearance of lithium is reduced by thiazides and ace inhibitors, increasing risk of lithium toxicity. monitor lithium levels. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Benazepril Hydrochloride And Hydrochlorothiazide and your doctor is considering prescribing Lithium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Benazepril Hydrochloride And Hydrochlorothiazide(Lotensin Hct)+💊 Lithium(Lithium)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
—
Source
NLP:benazepril hydrochloride and hydrochlorothiazide

What this means in plain English

Renal clearance of lithium is reduced by thiazides and ACE inhibitors, increasing risk of lithium toxicity. Monitor lithium levels.

What the FDA label says

"Reduced renal clearance by thiazides and ACE inhibitors"

📖 Source: NLP:benazepril hydrochloride and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.