Benazepril Hydrochloride And Hydrochlorothiazide has 16 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aliskiren, Angiotensin Ii, Everolimus. Patients taking Benazepril Hydrochloride And Hydrochlorothiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Contraindicated
- 1
- Major
- 8
- Moderate
- 3
- Minor
- 2
Contraindicated (1)
- Benazepril Hydrochloride And Hydrochlorothiazide + Aliskiren— Do not coadminister with benazepril/hydrochlorothiazide in patients with diabetes. Avoid in renal impairment (GFR < 60 m…
Major (8)
- Benazepril Hydrochloride And Hydrochlorothiazide + Angiotensin Ii— Dual RAS blockade associated with increased risks of hyperkalemia, hypertension, and acute renal failure. Avoid combined…
- Benazepril Hydrochloride And Hydrochlorothiazide + Everolimus— mTOR inhibitor coadministration with ACE inhibitor may increase risk for angioedema.
- Benazepril Hydrochloride And Hydrochlorothiazide + Lithium— Renal clearance of lithium is reduced by thiazides and ACE inhibitors, increasing risk of lithium toxicity. Monitor lith…
- Benazepril Hydrochloride And Hydrochlorothiazide + Mao Inhibitors— Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema.
- Benazepril Hydrochloride And Hydrochlorothiazide + Naproxen— NSAID that may result in deterioration of renal function and attenuate antihypertensive effects.
- Benazepril Hydrochloride And Hydrochlorothiazide + Nsaids— May result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-dep…
- Benazepril Hydrochloride And Hydrochlorothiazide + Rapamycin— mTOR inhibitor coadministration with ACE inhibitor may increase risk for angioedema.
- Benazepril Hydrochloride And Hydrochlorothiazide + Temsirolimus— mTOR inhibitor coadministration with ACE inhibitor may increase risk for angioedema.
Moderate (3)
- Benazepril Hydrochloride And Hydrochlorothiazide + Benazepril— Interactions Common for Both Benazepril and Hydrochlorothiazide Potassium Supplements and Potassium Sparing Diuretics: C…
- Benazepril Hydrochloride And Hydrochlorothiazide + Hydrochlorothiazide— Interactions Common for Both Benazepril and Hydrochlorothiazide Potassium Supplements and Potassium Sparing Diuretics: C…
- Benazepril Hydrochloride And Hydrochlorothiazide + Potassium Supplements— Concomitant use may affect potassium levels. Monitor potassium periodically.
Minor (2)
- Benazepril Hydrochloride And Hydrochlorothiazide + Acenocoumarol— No clinically important effects of benazepril identified in interaction studies.
- Benazepril Hydrochloride And Hydrochlorothiazide + Warfarin— No clinically important effects of benazepril on serum concentrations or clinical effects identified in interaction stud…