Does Buprenorphine Interact with Acetaminophen Caffeine Dihydrocodeine Bitartrate?
CDI records a moderate classification for Buprenorphine and Acetaminophen Caffeine Dihydrocodeine Bitartrate. The stored summary is: Mixed agonist/antagonist opioid may reduce the analgesic effect of this combination product. The mechanism involves opioid receptor antagonism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Buprenorphine Class
- Partial Opioid Agonist
- Acetaminophen Caffeine Dihydrocodeine Bitartrate Class
- Central Nervous System Stimulant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Opioid receptor antagonism
What To Tell Your Doctor or Pharmacist
If you are taking Buprenorphine and your doctor is considering prescribing Acetaminophen Caffeine Dihydrocodeine Bitartrate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider