Does Bupropion Hydrochloride Interact with Fluvoxamine?
Bupropion Hydrochloride and Fluvoxamine have a unknown drug interaction according to U.S. FDA drug labeling data. In vitro studies suggest fluvoxamine inhibits the hydroxylation of bupropion; no clinical studies performed to evaluate this finding. The mechanism involves inhibition of bupropion hydroxylation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Bupropion Hydrochloride and Fluvoxamine occurs because inhibition of bupropion hydroxylation. Clinically, this means in vitro studies suggest fluvoxamine inhibits the hydroxylation of bupropion; no clinical studies performed to evaluate this finding.
What To Tell Your Doctor or Pharmacist
If you are taking Bupropion Hydrochloride and your doctor is considering prescribing Fluvoxamine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider