Does Buspirone Interact with Amitriptyline?
Buspirone and Amitriptyline have a minor drug interaction according to U.S. FDA drug labeling data. Addition of buspirone to amitriptyline showed no statistically significant differences in steady-state pharmacokinetic parameters. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Buspirone and your doctor is considering prescribing Amitriptyline (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider