Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias and CNS stimulation, with accelerated onset of tricyclic action.
Source: NLP:levothyroxine sodium anhydrous
Amitriptyline Interactions
16 interactions on record
Tricyclic antidepressant that increases risk of serotonin syndrome with mirtazapine. Monitor for symptoms during initiation and dose increases.
Source: NLP:mirtazapine
Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.
Source: NLP:norepinephrine bitartrate
No statistically significant differences in steady-state pharmacokinetic parameters observed when buspirone added to amitriptyline regimen.
Source: NLP:buspirone hydrochloride
Amitriptyline in combination with clonidine enhances corneal lesion manifestation in animal studies; reduces hypotensive effect of clonidine.
Source: NLP:clonidine hydrochloride
Dosage adjustment of amitriptyline may be necessary when used concomitantly with divalproex sodium delayed-release tablets.
Source: NLP:divalproex sodium
Concomitant use may potentiate the cardiovascular effects of dopamine, including hypertension.
Source: NLP:dopamine hydrochloride
Amitriptyline + FluconazoleModerate
Fluconazole increases the effect of amitriptyline. Dosage adjustment may be necessary; monitor plasma levels.
Source: NLP:fluconazole
Amitriptyline + NabiloneModerate
Additive tachycardia, hypertension, and drowsiness reported with concurrent use.
Source: NLP:nabilone
Amitriptyline + NitroglycerinModerate
Tricyclic antidepressant may cause dry mouth and diminished salivary secretions, making sublingual nitroglycerin dissolution difficult.
Source: NLP:nitroglycerin
Amitriptyline + ParoxetineModerate
Paroxetine is a strong CYP2D6 inhibitor that may increase amitriptyline concentrations. Use caution and monitor.
Source: NLP:paroxetine
Amitriptyline + Valproate SodiumModerate
Dosage adjustment of amitriptyline may be necessary if used concomitantly with valproate due to altered pharmacokinetics.
Source: NLP:valproate sodium
Amitriptyline + Valproic AcidModerate
Dosage adjustment may be necessary if used concomitantly with valproic acid.
Source: NLP:valproic acid
Minor effect on risperidone exposure. Dose adjustment not needed.
Source: NLP:risperidone
Amitriptyline + ClonidineUnknown
Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in animal studies.
Source: NLP:clonidine
Amitriptyline in combination with clonidine enhances manifestation of corneal lesions in rats.
Source: NLP:clonidine transdermal system