Does Canagliflozin Interact with Lithium?
CDI records a moderate classification for Canagliflozin and Lithium. The stored summary is: Concomitant use may decrease serum lithium concentrations. Monitor serum lithium concentration more frequently during INVOKANA initiation and dosage changes. The mechanism involves decreased serum lithium concentration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased serum lithium concentration
What To Tell Your Doctor or Pharmacist
If you are taking Canagliflozin and your doctor is considering prescribing Lithium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider