Does Capecitabine Interact with Ixabepilone?
CDI records a minor classification for Capecitabine and Ixabepilone. The stored summary is: No clinically meaningful pharmacokinetic differences observed. Ixabepilone Cmax decreased 19%, capecitabine Cmax decreased 27%, 5-fluorouracil AUC increased 14%; interaction not clinically significant given supported efficacy data. The mechanism involves mutual pharmacokinetic effects with minimal clinical impact. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Minor
- Capecitabine Class
- Nucleoside Metabolic Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Mutual pharmacokinetic effects with minimal clinical impact
What To Tell Your Doctor or Pharmacist
If you are taking Capecitabine and your doctor is considering prescribing Ixabepilone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider