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Does Caplacizumab Interact with Selective Serotonin Reuptake Inhibitors Ssri?

Caplacizumab and Selective Serotonin Reuptake Inhibitors Ssri have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use may increase the risk of bleeding. Avoid concomitant use when possible and monitor closely for bleeding. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Major
Management: Close medical supervision required
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Caplacizumab and your doctor is considering prescribing Selective Serotonin Reuptake Inhibitors Ssri (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask how frequently you should be monitored while these are co-prescribed
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Caplacizumab(Cablivi)+💊 Selective Serotonin Reuptake Inhibitors Ssri

Severity & Interaction Details

⚠️

major

Use with caution — major interaction

Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:caplacizumab

What this means in plain English

Concomitant use may increase the risk of bleeding. Avoid concomitant use when possible and monitor closely for bleeding.

About Caplacizumab and Selective Serotonin Reuptake Inhibitors Ssri

Caplacizumab is also sold under the brand name Cablivi.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

PubMed

Serotonergic signaling in gastric physiology and motility disorders.about Selective Serotonin Reuptake Inhibitors Ssri · 2026-07

PubMed

Clinical symptoms and cognitive functioning following adjunctive N-acetylcysteine in obsessive-compulsive disorder: a double-blind, placebo-controlled trial.about Selective Serotonin Reuptake Inhibitors Ssri · 2026-06

PubMed

Evaluating Treatment Sequences in Major Depressive Disorder Using an Open-Source Health Economic Model Based on Stakeholder and Patient Engagement.about Selective Serotonin Reuptake Inhibitors Ssri · 2026-06

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.