Does Carbamazepine Interact with Sofosbuvir Velpatasvir And Voxilaprevir?
Carbamazepine and Sofosbuvir Velpatasvir And Voxilaprevir have a major drug interaction according to U.S. FDA drug labeling data. P-gp inducer and moderate to strong CYP inducer that may significantly decrease plasma concentrations of sofosbuvir, velpatasvir, and/or voxilaprevir, leading to reduced therapeutic effect. The mechanism involves p-gp induction and cyp2b6, cyp2c8, cyp3a4 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Carbamazepine Class
- Mood Stabilizer
- Sofosbuvir Velpatasvir And Voxilaprevir Class
- Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Carbamazepine and Sofosbuvir Velpatasvir And Voxilaprevir occurs because p-gp induction and cyp2b6, cyp2c8, cyp3a4 induction. Clinically, this means p-gp inducer and moderate to strong cyp inducer that may significantly decrease plasma concentrations of sofosbuvir, velpatasvir, and/or voxilaprevir, leading to reduced therapeutic effect. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Carbamazepine and your doctor is considering prescribing Sofosbuvir Velpatasvir And Voxilaprevir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider