Does Carbamazepine Interact with Valsartan And Hydrochlorothiazide?
CDI records a major classification for Carbamazepine and Valsartan And Hydrochlorothiazide. The stored summary is: May lead to symptomatic hyponatremia when administered concurrently with hydrochlorothiazide. The mechanism involves thiazide-induced hyponatremia potentiated by carbamazepine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Carbamazepine Class
- Mood Stabilizer
- Valsartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Thiazide-induced hyponatremia potentiated by carbamazepine
What To Tell Your Doctor or Pharmacist
If you are taking Carbamazepine and your doctor is considering prescribing Valsartan And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider