Does Carbidopa And Levodopa Interact with Ropinirole?
Carbidopa And Levodopa and Ropinirole have a minor drug interaction according to U.S. FDA drug labeling data. Co-administration had no effect on ropinirole steady-state pharmacokinetics. Ropinirole increased L-dopa Cmax by 20% but did not affect AUC. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Carbidopa And Levodopa Class
- Aromatic Amino Acid Decarboxylation Inhibitor
- Ropinirole Class
- Nonergot Dopamine Agonist
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Carbidopa And Levodopa and your doctor is considering prescribing Ropinirole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider