Ropinirole has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Metoclopramide, Metoclopramide Hydrochloride, Butyrophenones. Patients taking Ropinirole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Contraindicated
- 2
- Major
- 3
- Moderate
- 3
- Minor
- 5
Contraindicated (2)
- Ropinirole + Metoclopramide— Dopaminergic agonist with opposing effects on dopamine. Avoid concomitant use to prevent exacerbation of parkinsonian sy…
- Ropinirole + Metoclopramide Hydrochloride— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
Major (3)
- Ropinirole + Butyrophenones— Dopamine antagonists may diminish the effectiveness of ropinirole. Use in patients with major psychotic disorders only i…
- Ropinirole + Ciprofloxacin— CYP1A2 inhibitor increased ropinirole AUC by 84% and Cmax by 60%. Dose adjustment of ropinirole may be required.
- Ropinirole + Phenothiazines— Dopamine antagonists may diminish the effectiveness of ropinirole. Use in patients with major psychotic disorders only i…
Moderate (3)
- Ropinirole + Estrogens— Higher doses of estrogens reduce clearance of ropinirole; starting or stopping hormone replacement therapy may require r…
- Ropinirole + Ethinyl Estradiol— Estrogen that reduces oral clearance of ropinirole by 36%; starting or stopping may require dose adjustment of ropinirol…
- Ropinirole + Parathyroid Hormone— Higher doses of estrogens reduce clearance of ropinirole; starting or stopping HRT may require dose adjustment.
Minor (5)
- Ropinirole + Carbidopa— Coadministration with L-dopa and ropinirole had no effect on steady-state pharmacokinetics of ropinirole.
- Ropinirole + Carbidopa And Levodopa— Co-administration had no effect on ropinirole steady-state pharmacokinetics. Ropinirole increased L-dopa Cmax by 20% but…
- Ropinirole + Digoxin— Coadministration did not alter the steady-state pharmacokinetics of digoxin.
- Ropinirole + Methyldopa— Coadministration had no effect on steady-state pharmacokinetics of ropinirole; ropinirole increased mean steady-state Cm…
- Ropinirole + Theophylline— CYP1A2 substrate; coadministration did not alter steady-state pharmacokinetics of either drug.