Does Carvedilol Interact with Cinacalcet Hydrochloride?
CDI records a moderate classification for Carvedilol and Cinacalcet Hydrochloride. The stored summary is: Cinacalcet is a strong CYP2D6 inhibitor. Dose adjustments may be required for concomitant CYP2D6 substrate medications. The mechanism involves cinacalcet inhibits cyp2d6 metabolism of carvedilol. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Carvedilol Class
- alpha-Adrenergic Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Cinacalcet inhibits CYP2D6 metabolism of carvedilol
What To Tell Your Doctor or Pharmacist
If you are taking Carvedilol and your doctor is considering prescribing Cinacalcet Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider