Does Cinacalcet Hydrochloride Interact with Flecainide?
CDI records a major classification for Cinacalcet Hydrochloride and Flecainide. The stored summary is: Cinacalcet is a strong CYP2D6 inhibitor. Dose adjustments may be required, particularly for drugs with narrow therapeutic index such as flecainide. The mechanism involves cinacalcet inhibits cyp2d6 metabolism of flecainide. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Cinacalcet inhibits CYP2D6 metabolism of flecainide
What To Tell Your Doctor or Pharmacist
If you are taking Cinacalcet Hydrochloride and your doctor is considering prescribing Flecainide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider