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Does Chenodiol Interact with Cholestyramine Light?

Chenodiol and Cholestyramine Light have a contraindicated drug interaction according to U.S. FDA drug labeling data. Bile acid sequestering agent that decreases absorption of CHENODIOL in the intestine, resulting in decreased efficacy. Concomitant use should be avoided. The mechanism involves decreased intestinal absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Chenodiol Class
Bile Acid
Cholestyramine Light Class
Bile Acid Sequestrant
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Chenodiol and Cholestyramine Light occurs because decreased intestinal absorption. Clinically, this means bile acid sequestering agent that decreases absorption of chenodiol in the intestine, resulting in decreased efficacy. concomitant use should be avoided. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Chenodiol and your doctor is considering prescribing Cholestyramine Light (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Chenodiol(Ctexli)+💊 Cholestyramine Light(Questran)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Bile Acid
Drug B class
Bile Acid Sequestrant
Source
NLP:chenodiol

What this means in plain English

Bile acid sequestering agent that decreases absorption of CHENODIOL in the intestine, resulting in decreased efficacy. Concomitant use should be avoided.

About Chenodiol and Cholestyramine Light

Chenodiol is a Bile Acid, while Cholestyramine Light is a Bile Acid Sequestrant. You may recognize them by the brand names Ctexli and Questran. Both medications are taken by mouth. Chenodiol additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Decreased intestinal absorption"

📖 Source: NLP:chenodiol

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.