Does Chloral Hydrate Interact with Propofol Injectable Emulsion?
CDI records a major classification for Chloral Hydrate and Propofol Injectable Emulsion. The stored summary is: In combination with opioids, may reduce induction dose requirements and increase anesthetic/sedative effects with pronounced decreases in blood pressure and cardiac output. The mechanism involves enhanced anesthetic and sedative effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Propofol Injectable Emulsion Class
- General Anesthetic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enhanced anesthetic and sedative effects
What To Tell Your Doctor or Pharmacist
If you are taking Chloral Hydrate and your doctor is considering prescribing Propofol Injectable Emulsion (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider