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Does Chloral Hydrate Interact with Propofol Injectable Emulsion?

Chloral Hydrate and Propofol Injectable Emulsion have a major drug interaction according to U.S. FDA drug labeling data. In combination with opioids, may reduce induction dose requirements and increase anesthetic/sedative effects with pronounced decreases in blood pressure and cardiac output. The mechanism involves enhanced anesthetic and sedative effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Propofol Injectable Emulsion Class
General Anesthetic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Chloral Hydrate and Propofol Injectable Emulsion occurs because enhanced anesthetic and sedative effects. Clinically, this means in combination with opioids, may reduce induction dose requirements and increase anesthetic/sedative effects with pronounced decreases in blood pressure and cardiac output. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Chloral Hydrate and your doctor is considering prescribing Propofol Injectable Emulsion (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Chloral Hydrate+💊 Propofol Injectable Emulsion(Propofol Injectable Emulsion)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
General Anesthetic
Source
NLP:propofol injectable emulsion

What this means in plain English

In combination with opioids, may reduce induction dose requirements and increase anesthetic/sedative effects with pronounced decreases in blood pressure and cardiac output.

What the FDA label says

"Enhanced anesthetic and sedative effects"

📖 Source: NLP:propofol injectable emulsion

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.