Does Cholestyramine Light Interact with Hydrochlorothiazide?
CDI records a major classification for Cholestyramine Light and Hydrochlorothiazide. The stored summary is: Absorption of hydrochlorothiazide is impaired; single doses reduce absorption by up to 85%. The mechanism involves anionic exchange resin binds hydrochlorothiazide and reduces gastrointestinal tract absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Cholestyramine Light Class
- Bile Acid Sequestrant
- Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Anionic exchange resin binds hydrochlorothiazide and reduces gastrointestinal tract absorption
What To Tell Your Doctor or Pharmacist
If you are taking Cholestyramine Light and your doctor is considering prescribing Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider