Does Cimetidine Interact with Losartan Potassium And Hydrochlorothiazide?
Cimetidine and Losartan Potassium And Hydrochlorothiazide have a minor drug interaction according to U.S. FDA drug labeling data. Coadministration increased losartan AUC by approximately 18% but did not affect active metabolite pharmacokinetics. No significant clinical interaction. The mechanism involves cyp450 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Losartan Potassium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cimetidine and Losartan Potassium And Hydrochlorothiazide occurs because cyp450 inhibition. Clinically, this means coadministration increased losartan auc by approximately 18% but did not affect active metabolite pharmacokinetics. no significant clinical interaction. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Cimetidine and your doctor is considering prescribing Losartan Potassium And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider