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Losartan Potassium And Hydrochlorothiazide

Also known as: Losartan Potassium And Hydrochlorothiazide

Thiazide Diuretic

Route: Oral

Check Losartan Potassium And Hydrochlorothiazide Interactions →

20 interactions on record⛔ Black Box Warning

Losartan Potassium And Hydrochlorothiazide has 20 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Agents Increasing Serum Potassium, Aliskiren, Angiotensin Ii. Patients taking Losartan Potassium And Hydrochlorothiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 20
Major: 8
Moderate: 7
Minor: 5

Major (8)

Losartan Potassium And Hydrochlorothiazide + Agents Increasing Serum Potassium— Risk of hyperkalemia when coadministered with losartan. Monitor serum potassium in such patients.
Losartan Potassium And Hydrochlorothiazide + Aliskiren— Dual blockade of the renin-angiotensin system is associated with increased risks of hypotension, syncope, hyperkalemia, …
Losartan Potassium And Hydrochlorothiazide + Angiotensin Ii— Dual blockade of the renin-angiotensin system is associated with increased risks of hypotension, syncope, hyperkalemia, …
Losartan Potassium And Hydrochlorothiazide + Lisinopril— Combined use did not provide additional benefit versus monotherapy but increased incidence of hyperkalemia and acute kid…
Losartan Potassium And Hydrochlorothiazide + Lithium— Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use. Monitor lithium …
Losartan Potassium And Hydrochlorothiazide + Mao Inhibitors— Risk of deterioration of renal function including possible acute renal failure, and reduced diuretic and antihypertensiv…
Losartan Potassium And Hydrochlorothiazide + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Risk of deterioration of renal function including possible acute renal failure, and reduced diuretic, natriuretic, and a…
Losartan Potassium And Hydrochlorothiazide + Nsaids— May result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depl…

Moderate (7)

Losartan Potassium And Hydrochlorothiazide + Cholestyramine Light— Reduced absorption of thiazides. Monitor therapeutic effect of hydrochlorothiazide.
Losartan Potassium And Hydrochlorothiazide + Colestipol— Reduced absorption of thiazides. Monitor therapeutic effect of hydrochlorothiazide.
Losartan Potassium And Hydrochlorothiazide + Fluconazole— Fluconazole decreased active metabolite AUC by approximately 40% but increased losartan AUC by approximately 70%. Pharma…
Losartan Potassium And Hydrochlorothiazide + Hydrochlorothiazide— Monitor lithium levels in patients receiving losartan potassium and hydrochlorothiazide tablets and lithium. Hydrochloro…
Losartan Potassium And Hydrochlorothiazide + Losartan— ( 7.5 ) 7.1 Agents Increasing Serum Potassium Coadministration of losartan with other drugs that raise serum potassium l…
Losartan Potassium And Hydrochlorothiazide + Phenobarbital— Coadministration led to a reduction of about 20% in the AUC of losartan and its active metabolite. Monitor blood pressur…
Losartan Potassium And Hydrochlorothiazide + Rifampin— Rifampin decreased losartan AUC by approximately 30% and active metabolite AUC by approximately 40%. Inducer of drug met…

Minor (5)

Losartan Potassium And Hydrochlorothiazide + Cimetidine— Coadministration increased losartan AUC by approximately 18% but did not affect active metabolite pharmacokinetics. No s…
Losartan Potassium And Hydrochlorothiazide + Digoxin— Losartan did not affect the pharmacokinetics of oral or intravenous digoxin. No significant interaction found.
Losartan Potassium And Hydrochlorothiazide + Erythromycin— Erythromycin increased losartan AUC by 30% but had no clinically significant effect on active metabolite. No significant…
Losartan Potassium And Hydrochlorothiazide + Ketoconazole— Ketoconazole did not affect conversion of losartan to active metabolite after intravenous administration. No clinically …
Losartan Potassium And Hydrochlorothiazide + Warfarin— Losartan did not affect the pharmacokinetics or pharmacodynamics of warfarin. No significant drug-drug pharmacokinetic i…

Losartan Potassium And Hydrochlorothiazide + Agents Increasing Serum Potassium⚠️Major

Risk of hyperkalemia when coadministered with losartan. Monitor serum potassium in such patients.

Losartan Potassium And Hydrochlorothiazide + Aliskiren⚠️Major

Dual blockade of the renin-angiotensin system is associated with increased risks of hypotension, syncope, hyperkalemia, and changes in renal function including acute renal failure.

Losartan Potassium And Hydrochlorothiazide + Angiotensin Ii⚠️Major

Dual blockade of the renin-angiotensin system is associated with increased risks of hypotension, syncope, hyperkalemia, and changes in renal function including acute renal failure.

Losartan Potassium And Hydrochlorothiazide + Lisinopril⚠️Major

Combined use did not provide additional benefit versus monotherapy but increased incidence of hyperkalemia and acute kidney injury.

Losartan Potassium And Hydrochlorothiazide + Lithium⚠️Major

Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use. Monitor lithium levels in patients receiving both drugs.

Losartan Potassium And Hydrochlorothiazide + Mao Inhibitors⚠️Major

Risk of deterioration of renal function including possible acute renal failure, and reduced diuretic and antihypertensive effects. Monitor renal function periodically.

Losartan Potassium And Hydrochlorothiazide + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)⚠️Major

Risk of deterioration of renal function including possible acute renal failure, and reduced diuretic, natriuretic, and antihypertensive effects. Monitor renal function periodically.

Losartan Potassium And Hydrochlorothiazide + Nsaids⚠️Major

May result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. Antihypertensive effect may be attenuated.

Losartan Potassium And Hydrochlorothiazide + Cholestyramine Light🟡Moderate

Reduced absorption of thiazides. Monitor therapeutic effect of hydrochlorothiazide.

Losartan Potassium And Hydrochlorothiazide + Colestipol🟡Moderate

Reduced absorption of thiazides. Monitor therapeutic effect of hydrochlorothiazide.

Losartan Potassium And Hydrochlorothiazide + Fluconazole🟡Moderate

Fluconazole decreased active metabolite AUC by approximately 40% but increased losartan AUC by approximately 70%. Pharmacodynamic consequences not fully examined.

Losartan Potassium And Hydrochlorothiazide + Hydrochlorothiazide🟡Moderate

Monitor lithium levels in patients receiving losartan potassium and hydrochlorothiazide tablets and lithium. Hydrochlorothiazide The administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when losartan potassium and hydrochlorothiazide tablets and non-steroidal anti-inflammatory agents including selective COX-2 inhibitors are used concomitantly, observe closely to determine if the desired effect of the diuretic is obtained.

Losartan Potassium And Hydrochlorothiazide + Losartan🟡Moderate

( 7.5 ) 7.1 Agents Increasing Serum Potassium Coadministration of losartan with other drugs that raise serum potassium levels may result in hyperkalemia. Monitor lithium levels in patients receiving losartan potassium and hydrochlorothiazide tablets and lithium. 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors Losartan Potassium In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including losartan) may result in deterioration of renal function, including possible acute renal failure.

Losartan Potassium And Hydrochlorothiazide + Phenobarbital🟡Moderate

Coadministration led to a reduction of about 20% in the AUC of losartan and its active metabolite. Monitor blood pressure control.

Losartan Potassium And Hydrochlorothiazide + Rifampin🟡Moderate

Rifampin decreased losartan AUC by approximately 30% and active metabolite AUC by approximately 40%. Inducer of drug metabolism may reduce efficacy.

Losartan Potassium And Hydrochlorothiazide + Cimetidine🟢Minor

Coadministration increased losartan AUC by approximately 18% but did not affect active metabolite pharmacokinetics. No significant clinical interaction.

Losartan Potassium And Hydrochlorothiazide + Digoxin🟢Minor

Losartan did not affect the pharmacokinetics of oral or intravenous digoxin. No significant interaction found.

Losartan Potassium And Hydrochlorothiazide + Erythromycin🟢Minor

Erythromycin increased losartan AUC by 30% but had no clinically significant effect on active metabolite. No significant interaction.

Losartan Potassium And Hydrochlorothiazide + Ketoconazole🟢Minor

Ketoconazole did not affect conversion of losartan to active metabolite after intravenous administration. No clinically significant interaction.

Losartan Potassium And Hydrochlorothiazide + Warfarin🟢Minor

Losartan did not affect the pharmacokinetics or pharmacodynamics of warfarin. No significant drug-drug pharmacokinetic interaction found.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.