Does Cimetidine Interact with Pioglitazole And Metformin Hydrochloride?
Cimetidine and Pioglitazole And Metformin Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. Reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis. Consider benefits and risks of concomitant use. The mechanism involves inhibits renal tubular transport of metformin (oct2/mate). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cimetidine and Pioglitazole And Metformin Hydrochloride occurs because inhibits renal tubular transport of metformin (oct2/mate). Clinically, this means reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis. consider benefits and risks of concomitant use. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Cimetidine and your doctor is considering prescribing Pioglitazole And Metformin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider