Does Clarithromycin Interact with Disopyramide?
CDI records a major classification for Clarithromycin and Disopyramide. The stored summary is: Postmarketing reports of torsades de pointes with concurrent use. CYP3A-based interaction may increase disopyramide concentrations. Hypoglycemia reported with concomitant administration. The mechanism involves cyp3a inhibition by clarithromycin; increased serum concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Clarithromycin Class
- Macrolide Antimicrobial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A inhibition by clarithromycin; increased serum concentrations
What To Tell Your Doctor or Pharmacist
If you are taking Clarithromycin and your doctor is considering prescribing Disopyramide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider