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Does Clindamycin Phosphate And Tretinoin Gel 120025 Interact with Erythromycin?

Clindamycin Phosphate And Tretinoin Gel 120025 and Erythromycin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Should not be used in combination due to possible antagonism between clindamycin and erythromycin. In-vitro studies show antagonism between these antimicrobials. The mechanism involves antagonism between clindamycin and erythromycin antimicrobials. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Clindamycin Phosphate And Tretinoin Gel 120025 Class
Retinoid
Erythromycin Class
Macrolide
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Clindamycin Phosphate And Tretinoin Gel 120025 and Erythromycin occurs because antagonism between clindamycin and erythromycin antimicrobials. Clinically, this means should not be used in combination due to possible antagonism between clindamycin and erythromycin. in-vitro studies show antagonism between these antimicrobials. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Clindamycin Phosphate And Tretinoin Gel 120025 and your doctor is considering prescribing Erythromycin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Clindamycin Phosphate And Tretinoin Gel 120025(Ziana)+💊 Erythromycin(Benzamycin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Retinoid
Drug B class
Macrolide
Source
NLP:clindamycin phosphate and tretinoin gel 1.2%/0.025%

What this means in plain English

Should not be used in combination due to possible antagonism between clindamycin and erythromycin. In-vitro studies show antagonism between these antimicrobials.

About Clindamycin Phosphate And Tretinoin Gel 120025 and Erythromycin

Clindamycin Phosphate And Tretinoin Gel 120025 is a Retinoid, while Erythromycin is a Macrolide. You may recognize them by the brand names Ziana and Benzamycin. Clindamycin Phosphate And Tretinoin Gel 120025 is applied to the skin, whereas Erythromycin is taken by mouth.

What the FDA label says

"Antagonism between clindamycin and erythromycin antimicrobials"

📖 Source: NLP:clindamycin phosphate and tretinoin gel 1.2%/0.025%

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.