Clonidine + Metoprolol Tartrate And Hydrochlorothiazide Interaction
Majorinteraction on record
Description
Beta-blocker withdrawal several days before clonidine withdrawal required to avoid exacerbating rebound hypertension; concomitant use also increases risk of bradycardia.
Mechanism
Additive atrioventricular effects and beta-blocker rebound hypertension
Source: NLP:metoprolol tartrate and hydrochlorothiazide