Home›Clonidine

Clonidine

Also known as: Clonidine

Central alpha-2 Adrenergic AgonistAdrenergic alpha2-Agonists

Route: Oral

65 interactions on record⛔ Black Box Warning

Clonidine has 65 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 33 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Metoprolol Tartrate, Amiodarone Hydrochloride, Atenolol. Patients taking Clonidine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 65
Contraindicated: 1
Major: 33
Moderate: 31

Contraindicated (1)

Clonidine + Metoprolol Tartrate— Metoprolol may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before g…

Major (33)

Clonidine + Amiodarone Hydrochloride— Negative chronotrope. Potentiates electrophysiologic and hemodynamic effects resulting in bradycardia, sinus arrest, and…
Clonidine + Atenolol— Beta-blockers may exacerbate rebound hypertension following clonidine withdrawal; careful withdrawal timing required.
Clonidine + Atenolol And Chlorthalidone— Beta-blockers may exacerbate rebound hypertension following clonidine withdrawal; beta-blocker should be withdrawn sever…
Clonidine + Betaxolol— Beta-blocker should be discontinued slowly over several days before gradual withdrawal of clonidine to avoid rebound hyp…
Clonidine + Bisoprolol Fumarate— Bisoprolol fumarate should be discontinued several days before clonidine withdrawal to avoid excessive sympathetic rebou…
Clonidine + Bisoprolol Fumarate And Hydrochlorothiazide— Bisoprolol should be discontinued several days before clonidine withdrawal to avoid rebound hypertension and excessive s…
Clonidine + Calcium Channel Blockers— Additive effects such as bradycardia and AV block may occur. Sinus bradycardia resulting in hospitalization and pacemake…
Clonidine + Carvedilol— May cause hypotension and bradycardia; beta-blocker should be discontinued first when terminating concomitant therapy.
Clonidine + Carvedilol Phosphate— Concomitant use may cause hypotension and bradycardia; beta-blocker should be discontinued first when stopping both drug…
Clonidine + Clomipramine Hydrochloride— Tricyclic antidepressants block the pharmacologic effects of clonidine; such an effect may be anticipated with clomipram…
Clonidine + Crizotinib— Clonidine causes bradycardia and should be avoided with crizotinib, which can also cause bradycardia.
Clonidine + Digitalis Glycosides— Additive effects on sinus node function and AV nodal conduction, potentially causing bradycardia and AV block. Monitor h…
Clonidine + Diltiazem— Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with clonidine and diltiazem co…
Clonidine + Diltiazem Hydrochloride— Sinus bradycardia resulting in hospitalization and pacemaker insertion reported with concurrent use. Heart rate monitori…
Clonidine + Epinephrine— Potentiates pressor effects of epinephrine.
Clonidine + Esmolol Hydrochloride— Beta blockers increase risk of clonidine-withdrawal rebound hypertension. If antihypertensive therapy must be interrupte…
Clonidine + Fluphenazine— One reported case of acute delirium with simultaneous use of fluphenazine and oral clonidine; symptoms resolved when clo…
Clonidine + Metoprolol— Increases bradycardia risk; beta-blockers may exacerbate rebound hypertension following clonidine withdrawal. Withdraw m…
Clonidine + Metoprolol Succinate— Beta-blocker may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before…
Clonidine + Metoprolol Succinate Er— Concomitant use increases bradycardia risk. Withdraw beta-blocker several days before clonidine withdrawal to avoid rebo…
Clonidine + Metoprolol Succinate Er Tablets— Beta-blocker may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before…
Clonidine + Metoprolol Tartrate And Hydrochlorothiazide— Beta-blocker withdrawal several days before clonidine withdrawal required to avoid exacerbating rebound hypertension; co…
Clonidine + Nebivolol— Discontinue nebivolol several days before gradual tapering of clonidine to avoid excessive reduction of sympathetic acti…
Clonidine + Nebivolol Hydrochloride— May produce excessive reduction of sympathetic activity. Nebivolol must be discontinued several days before gradual tape…
Clonidine + Nonselective Beta-Adrenergic Antagonists— Beta-blockers may exacerbate the hypertensive response seen with clonidine withdrawal. Additive effects such as bradycar…
Clonidine + Phenylephrine Hci— α-2 adrenergic agonist that increases the pressor effect of phenylephrine hydrochloride.
Clonidine + Phenylephrine Hydrochloride— α-2 adrenergic agonist that increases the pressor effect of phenylephrine hydrochloride.
Clonidine + Phenylephrine Hydrochloride Injection, Solution— Alpha-2 adrenergic agonist increases pressor effect of phenylephrine hydrochloride.
Clonidine + Propranolol Hydrochloride— Beta-blockers may antagonize clonidine's antihypertensive effects and rebound hypertension may result if clonidine is wi…
Clonidine + Sotalol Hydrochloride— Concomitant use increases risk of bradycardia and rebound hypertension upon discontinuation. Withdraw sotalol several da…
Clonidine + Timolol Maleate— Beta-blockers may exacerbate rebound hypertension following clonidine withdrawal; staggered discontinuation required.
Clonidine + Verapamil— Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with clonidine and verapamil co…
Clonidine + Verapamil Hydrochloride— Sinus bradycardia resulting in hospitalization and pacemaker insertion reported. Monitor heart rate during concurrent us…

Moderate (31)

Clonidine + Alcohol— Clonidine may potentiate the CNS-depressive effects of alcohol.
Clonidine + Amitriptyline— Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions.
Clonidine + Apraclonidine— Caution advised with simultaneous use of clonidine and other similar pharmacologic agents.
Clonidine + Barbiturates— Clonidine may potentiate the CNS-depressive effects of barbiturates.
Clonidine + Clomipramine Hydrochloride Capsules— Tricyclic antidepressants including clomipramine may block the pharmacologic effects of clonidine.
Clonidine + Dorzolamide Hydrochloride And Timolol Maleate Preservative Free— Oral beta-adrenergic blocking agents may exacerbate rebound hypertension.
Clonidine + Ephedrine Sulfate— Augments pressor effect of ephedrine. Carefully monitor blood pressure.
Clonidine + Epinephrine In Sodium Chloride— Potentiates the effects of epinephrine.
Clonidine + Glimepiride— May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglyc…
Clonidine + Glipizide— May lead to either potentiation or weakening of glucose-lowering effect; may mask hypoglycemia signs.
Clonidine + Insulin Aspart Injection— May increase or decrease the blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Increased glucose m…
Clonidine + Insulin Aspart-Szjj— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Increased glucose monit…
Clonidine + Insulin Degludec— May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and incr…
Clonidine + Insulin Degludec And Liraglutide— May increase or decrease blood glucose-lowering effect and may blunt signs/symptoms of hypoglycemia; dosage adjustment a…
Clonidine + Insulin Detemir— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dosage adjustment a…
Clonidine + Insulin Glargine— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dosage adjustment and i…
Clonidine + Insulin Glargine And Lixisenatide— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and…
Clonidine + Insulin Glargine-Aglr— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and inc…
Clonidine + Insulin Glargine-Yfgn— May increase or decrease blood glucose lowering effect and may blunt hypoglycemia signs/symptoms. Dosage adjustment and …
Clonidine + Insulin Glulisine— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and…
Clonidine + Insulin Human— May increase or decrease blood glucose effect and blunt hypoglycemia signs; increased glucose monitoring required.
Clonidine + Insulin Icodec-Abae— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and inc…
Clonidine + Insulin Lispro— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia; increased glucose m…
Clonidine + Insulin Lispro-Aabc— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and inc…
Clonidine + Macimorelin Acetate— May transiently elevate growth hormone concentrations and impact accuracy of MACRILEN diagnostic test. Avoid concomitant…
Clonidine + Nateglinide— May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.
Clonidine + Nexterone (Amiodarone Hci)— Concomitant use can potentiate electrophysiologic and hemodynamic effects, resulting in bradycardia, sinus arrest, and A…
Clonidine + Opioid Analgesics— Narcotic analgesics may potentiate the hypotensive effects of clonidine.
Clonidine + Timolol Hemihydrate— Oral beta-blockers may exacerbate rebound hypertension following clonidine withdrawal, though no reports with ophthalmic…
Clonidine + Timolol Maleate Ophthalmic Gel Forming Solution 0.25%— Oral beta-adrenergic blocking agents may exacerbate rebound hypertension following clonidine withdrawal; no reports with…
Clonidine + Topical Local Anesthetics— Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including sensory an…

Clonidine + Metoprolol Tartrate⛔Contraindicated

Metoprolol may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal.

Clonidine + Amiodarone Hydrochloride⚠️Major

Negative chronotrope. Potentiates electrophysiologic and hemodynamic effects resulting in bradycardia, sinus arrest, and AV block.

Clonidine + Atenolol⚠️Major

Beta-blockers may exacerbate rebound hypertension following clonidine withdrawal; careful withdrawal timing required.

Clonidine + Atenolol And Chlorthalidone⚠️Major

Beta-blockers may exacerbate rebound hypertension following clonidine withdrawal; beta-blocker should be withdrawn several days before gradual clonidine cessation.

Clonidine + Betaxolol⚠️Major

Beta-blocker should be discontinued slowly over several days before gradual withdrawal of clonidine to avoid rebound hypertension.

Clonidine + Bisoprolol Fumarate⚠️Major

Bisoprolol fumarate should be discontinued several days before clonidine withdrawal to avoid excessive sympathetic rebound.

Clonidine + Bisoprolol Fumarate And Hydrochlorothiazide⚠️Major

Bisoprolol should be discontinued several days before clonidine withdrawal to avoid rebound hypertension and excessive sympathetic reduction.

Clonidine + Calcium Channel Blockers⚠️Major

Additive effects such as bradycardia and AV block may occur. Sinus bradycardia resulting in hospitalization and pacemaker insertion reported with diltiazem or verapamil.

Clonidine + Carvedilol⚠️Major

May cause hypotension and bradycardia; beta-blocker should be discontinued first when terminating concomitant therapy.

Clonidine + Carvedilol Phosphate⚠️Major

Concomitant use may cause hypotension and bradycardia; beta-blocker should be discontinued first when stopping both drugs.

Clonidine + Clomipramine Hydrochloride⚠️Major

Tricyclic antidepressants block the pharmacologic effects of clonidine; such an effect may be anticipated with clomipramine due to structural similarity.

Clonidine + Crizotinib⚠️Major

Clonidine causes bradycardia and should be avoided with crizotinib, which can also cause bradycardia.

Clonidine + Digitalis Glycosides⚠️Major

Additive effects on sinus node function and AV nodal conduction, potentially causing bradycardia and AV block. Monitor heart rate.

Clonidine + Diltiazem⚠️Major

Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with clonidine and diltiazem concomitantly.

Clonidine + Diltiazem Hydrochloride⚠️Major

Sinus bradycardia resulting in hospitalization and pacemaker insertion reported with concurrent use. Heart rate monitoring required.

Clonidine + Epinephrine⚠️Major

Potentiates pressor effects of epinephrine.

Clonidine + Esmolol Hydrochloride⚠️Major

Beta blockers increase risk of clonidine-withdrawal rebound hypertension. If antihypertensive therapy must be interrupted, discontinue beta blocker first and gradually.

Clonidine + Fluphenazine⚠️Major

One reported case of acute delirium with simultaneous use of fluphenazine and oral clonidine; symptoms resolved when clonidine withdrawn and recurred on rechallenge.

Clonidine + Metoprolol⚠️Major

Increases bradycardia risk; beta-blockers may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal.

Clonidine + Metoprolol Succinate⚠️Major

Beta-blocker may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal, or delay metoprolol introduction for several days after stopping clonidine.

Clonidine + Metoprolol Succinate Er⚠️Major

Concomitant use increases bradycardia risk. Withdraw beta-blocker several days before clonidine withdrawal to avoid rebound hypertension exacerbation.

Clonidine + Metoprolol Succinate Er Tablets⚠️Major

Beta-blocker may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal.

Clonidine + Metoprolol Tartrate And Hydrochlorothiazide⚠️Major

Beta-blocker withdrawal several days before clonidine withdrawal required to avoid exacerbating rebound hypertension; concomitant use also increases risk of bradycardia.

Clonidine + Nebivolol⚠️Major

Discontinue nebivolol several days before gradual tapering of clonidine to avoid excessive reduction of sympathetic activity.

Clonidine + Nebivolol Hydrochloride⚠️Major

May produce excessive reduction of sympathetic activity. Nebivolol must be discontinued several days before gradual tapering of clonidine.

Clonidine + Nonselective Beta-Adrenergic Antagonists⚠️Major

Beta-blockers may exacerbate the hypertensive response seen with clonidine withdrawal. Additive effects such as bradycardia and AV block may occur.

Clonidine + Phenylephrine Hci⚠️Major

α-2 adrenergic agonist that increases the pressor effect of phenylephrine hydrochloride.

Clonidine + Phenylephrine Hydrochloride⚠️Major

α-2 adrenergic agonist that increases the pressor effect of phenylephrine hydrochloride.

Clonidine + Phenylephrine Hydrochloride Injection, Solution⚠️Major

Alpha-2 adrenergic agonist increases pressor effect of phenylephrine hydrochloride.

Clonidine + Propranolol Hydrochloride⚠️Major

Beta-blockers may antagonize clonidine's antihypertensive effects and rebound hypertension may result if clonidine is withdrawn abruptly. Withdraw beta-blocker several days before clonidine withdrawal.

Clonidine + Sotalol Hydrochloride⚠️Major

Concomitant use increases risk of bradycardia and rebound hypertension upon discontinuation. Withdraw sotalol several days before gradual clonidine withdrawal.

Clonidine + Timolol Maleate⚠️Major

Beta-blockers may exacerbate rebound hypertension following clonidine withdrawal; staggered discontinuation required.

Clonidine + Verapamil⚠️Major

Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with clonidine and verapamil concomitantly.

Clonidine + Verapamil Hydrochloride⚠️Major

Sinus bradycardia resulting in hospitalization and pacemaker insertion reported. Monitor heart rate during concurrent use.

Clonidine + Alcohol🟡Moderate

Clonidine may potentiate the CNS-depressive effects of alcohol.

Clonidine + Amitriptyline🟡Moderate

Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions.

Clonidine + Apraclonidine🟡Moderate

Caution advised with simultaneous use of clonidine and other similar pharmacologic agents.

Clonidine + Barbiturates🟡Moderate

Clonidine may potentiate the CNS-depressive effects of barbiturates.

Clonidine + Clomipramine Hydrochloride Capsules🟡Moderate

Tricyclic antidepressants including clomipramine may block the pharmacologic effects of clonidine.

Clonidine + Dorzolamide Hydrochloride And Timolol Maleate Preservative Free🟡Moderate

Oral beta-adrenergic blocking agents may exacerbate rebound hypertension.

Clonidine + Ephedrine Sulfate🟡Moderate

Augments pressor effect of ephedrine. Carefully monitor blood pressure.

Clonidine + Epinephrine In Sodium Chloride🟡Moderate

Potentiates the effects of epinephrine.

Clonidine + Glimepiride🟡Moderate

May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglycemia.

Clonidine + Glipizide🟡Moderate

May lead to either potentiation or weakening of glucose-lowering effect; may mask hypoglycemia signs.

Clonidine + Insulin Aspart Injection🟡Moderate

May increase or decrease the blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Increased glucose monitoring required.

Clonidine + Insulin Aspart-Szjj🟡Moderate

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Increased glucose monitoring required.

Clonidine + Insulin Degludec🟡Moderate

May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and increased glucose monitoring may be required.

Clonidine + Insulin Degludec And Liraglutide🟡Moderate

May increase or decrease blood glucose-lowering effect and may blunt signs/symptoms of hypoglycemia; dosage adjustment and increased glucose monitoring required.

Clonidine + Insulin Detemir🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dosage adjustment and increased glucose monitoring required.

Clonidine + Insulin Glargine🟡Moderate

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dosage adjustment and increased glucose monitoring required.

Clonidine + Insulin Glargine And Lixisenatide🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Clonidine + Insulin Glargine-Aglr🟡Moderate

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Clonidine + Insulin Glargine-Yfgn🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt hypoglycemia signs/symptoms. Dosage adjustment and increased glucose monitoring required.

Clonidine + Insulin Glulisine🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Clonidine + Insulin Human🟡Moderate

May increase or decrease blood glucose effect and blunt hypoglycemia signs; increased glucose monitoring required.

Clonidine + Insulin Icodec-Abae🟡Moderate

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Clonidine + Insulin Lispro🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia; increased glucose monitoring required.

Clonidine + Insulin Lispro-Aabc🟡Moderate

May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dose adjustment and increased glucose monitoring required.

Clonidine + Macimorelin Acetate🟡Moderate

May transiently elevate growth hormone concentrations and impact accuracy of MACRILEN diagnostic test. Avoid concomitant use.

Clonidine + Nateglinide🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased frequency of glucose monitoring may be required.

Clonidine + Nexterone (Amiodarone Hci)🟡Moderate

Concomitant use can potentiate electrophysiologic and hemodynamic effects, resulting in bradycardia, sinus arrest, and AV block.

Clonidine + Opioid Analgesics🟡Moderate

Narcotic analgesics may potentiate the hypotensive effects of clonidine.

Clonidine + Timolol Hemihydrate🟡Moderate

Oral beta-blockers may exacerbate rebound hypertension following clonidine withdrawal, though no reports with ophthalmic timolol.

Clonidine + Timolol Maleate Ophthalmic Gel Forming Solution 0.25%🟡Moderate

Oral beta-adrenergic blocking agents may exacerbate rebound hypertension following clonidine withdrawal; no reports with ophthalmic timolol maleate.

Clonidine + Topical Local Anesthetics🟡Moderate

Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including sensory and motor blockade.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.