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Does Clopidogrel Bisulfate Interact with Omeprazole?

Clopidogrel Bisulfate and Omeprazole have a contraindicated drug interaction according to U.S. FDA drug labeling data. Avoid concomitant use. Omeprazole significantly reduces the antiplatelet activity of clopidogrel bisulfate when given concomitantly or 12 hours apart. The mechanism involves cyp2c19 inhibition reduces plasma concentrations of clopidogrel active metabolite. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Omeprazole Class
Proton Pump Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Clopidogrel Bisulfate and Omeprazole occurs because cyp2c19 inhibition reduces plasma concentrations of clopidogrel active metabolite. Clinically, this means avoid concomitant use. omeprazole significantly reduces the antiplatelet activity of clopidogrel bisulfate when given concomitantly or 12 hours apart. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Clopidogrel Bisulfate and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Clopidogrel Bisulfate(Clopidogrel)+💊 Omeprazole

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Proton Pump Inhibitor
Source
NLP:clopidogrel bisulfate

What this means in plain English

Avoid concomitant use. Omeprazole significantly reduces the antiplatelet activity of clopidogrel bisulfate when given concomitantly or 12 hours apart.

What the FDA label says

"CYP2C19 inhibition reduces plasma concentrations of clopidogrel active metabolite"

📖 Source: NLP:clopidogrel bisulfate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.