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Does Cobicistat Interact with Mometasone Furoate?

Cobicistat and Mometasone Furoate have a moderate drug interaction according to U.S. FDA drug labeling data. Strong CYP3A4 inhibitor (as cobicistat-containing products) that may increase systemic corticosteroid effects. Use with caution and monitor for systemic corticosteroid side effects. The mechanism involves inhibition of cyp3a4 metabolism of mometasone furoate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Cobicistat Class
Cytochrome P450 3A Inhibitor
Mometasone Furoate Class
Corticosteroid
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cobicistat and Mometasone Furoate occurs because inhibition of cyp3a4 metabolism of mometasone furoate. Clinically, this means strong cyp3a4 inhibitor (as cobicistat-containing products) that may increase systemic corticosteroid effects. use with caution and monitor for systemic corticosteroid side effects. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Cobicistat and your doctor is considering prescribing Mometasone Furoate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cobicistat(Tybost)+💊 Mometasone Furoate(Propel)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Cytochrome P450 3A Inhibitor
Drug B class
Corticosteroid
Source
NLP:mometasone furoate

What this means in plain English

Strong CYP3A4 inhibitor (as cobicistat-containing products) that may increase systemic corticosteroid effects. Use with caution and monitor for systemic corticosteroid side effects.

About Cobicistat and Mometasone Furoate

Cobicistat is a Cytochrome P450 3A Inhibitor, while Mometasone Furoate is a Corticosteroid. You may recognize them by the brand names Tybost and Propel. Cobicistat is taken by mouth, whereas Mometasone Furoate is given as a nasal spray.

What the FDA label says

"Inhibition of CYP3A4 metabolism of mometasone furoate"

📖 Source: NLP:mometasone furoate

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.