Does Colesevelam Interact with Odevixibat?
CDI records a moderate classification for Colesevelam and Odevixibat. The stored summary is: Bile acid binding resins may bind odevixibat in the gut, reducing BYLVAY efficacy. Administer at least 4 hours before or after odevixibat. The mechanism involves binding in the gut reducing drug efficacy. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Odevixibat Class
- Ileal Bile Acid Transporter Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Binding in the gut reducing drug efficacy
What To Tell Your Doctor or Pharmacist
If you are taking Colesevelam and your doctor is considering prescribing Odevixibat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider