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Does Colesevelam Hydrochloride Interact with Colesevelam?

Colesevelam Hydrochloride and Colesevelam have a unknown drug interaction according to U.S. FDA drug labeling data. 7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Administer these drugs 4 hours prior to colesevelam hydrochloride. Concomitant use with colesevelam hydrochloride may increase the exposure of the following drugs: Metformin extended release. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Unknown
Management: Consult your pharmacist
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Colesevelam Hydrochloride and your doctor is considering prescribing Colesevelam (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Colesevelam Hydrochloride(Welchol)+💊 Colesevelam(Welchol)

Severity & Interaction Details

ℹ️

unknown

Interaction documented — severity unclassified

The FDA label notes an interaction but the severity is not classified in our dataset.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

FDA drug label - colesevelam hydrochloride

What this means in plain English

7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Administer these drugs 4 hours prior to colesevelam hydrochloride. Concomitant use with colesevelam hydrochloride may increase the exposure of the following drugs: Metformin extended release.

About Colesevelam Hydrochloride and Colesevelam

You may recognize them by the brand names Welchol and Welchol. Both medications are taken by mouth.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.