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Colesevelam Hydrochloride

Also known as: Colesevelam Hydrochloride

Route: Oral

Check Colesevelam Hydrochloride Interactions →

18 interactions on record

Colesevelam Hydrochloride has 18 known drug interactions based on U.S. FDA drug labeling data. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclosporine, Ethinyl Estradiol, Glibenclamide. Patients taking Colesevelam Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 18
Major: 10
Moderate: 6

Major (10)

Colesevelam Hydrochloride + Cyclosporine— Colesevelam may decrease cyclosporine exposure. In vivo studies showed decreased exposure when coadministered.
Colesevelam Hydrochloride + Ethinyl Estradiol— Colesevelam may decrease ethinyl estradiol exposure when coadministered with oral contraceptives. In vivo studies demons…
Colesevelam Hydrochloride + Glibenclamide— Colesevelam may decrease sulfonylurea exposure. Administer glyburide 4 hours prior to colesevelam.
Colesevelam Hydrochloride + Glimepiride— Colesevelam may decrease sulfonylurea exposure. Administer glimepiride 4 hours prior to colesevelam.
Colesevelam Hydrochloride + Glipizide— Colesevelam may decrease sulfonylurea exposure. Administer glipizide 4 hours prior to colesevelam.
Colesevelam Hydrochloride + Levothyroxine— In vivo studies showed decreased levothyroxine exposure. Postmarketing reports of elevated TSH in patients on thyroid ho…
Colesevelam Hydrochloride + Norethindrone— Colesevelam may decrease norethindrone exposure when coadministered with oral contraceptives. In vivo studies demonstrat…
Colesevelam Hydrochloride + Olmesartan Medoxomil— Colesevelam may decrease olmesartan medoxomil exposure. Administer olmesartan medoxomil 4 hours prior to colesevelam.
Colesevelam Hydrochloride + Phenytoin— Postmarketing reports of increased seizure activity or decreased phenytoin levels in patients receiving phenytoin with c…
Colesevelam Hydrochloride + Warfarin— Postmarketing reports of reduced INR in patients receiving warfarin. Frequent INR monitoring required during initiation …

Moderate (6)

Colesevelam Hydrochloride + Amlodipine Besylate And Olmesartan Medoxomil— Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose.
Colesevelam Hydrochloride + Metformin Extended Release— WELCHOL may increase exposure of metformin extended release. Monitor patients' glycemic control.
Colesevelam Hydrochloride + Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide— Reduces systemic exposure and peak plasma concentration of olmesartan. Administer olmesartan at least 4 hours before col…
Colesevelam Hydrochloride + Olmesartan Medoxomil And Amlodipine Besylate And Hydrochlorothiazide— Reduces systemic exposure and peak plasma concentration of olmesartan. Administer olmesartan at least 4 hours before col…
Colesevelam Hydrochloride + Olmesartan Medoxomil And Hydrochlorothiazide— May reduce absorption of olmesartan. Administer olmesartan at least 4 hours before colesevelam hydrochloride dose.
Colesevelam Hydrochloride + Olmesartan Medoxomil-Hydrochlorothiazide— Reduces systemic exposure and peak plasma concentration of olmesartan. Consider administering olmesartan at least 4 hour…

Colesevelam Hydrochloride + Cyclosporine⚠️Major

Colesevelam may decrease cyclosporine exposure. In vivo studies showed decreased exposure when coadministered.

Colesevelam Hydrochloride + Ethinyl Estradiol⚠️Major

Colesevelam may decrease ethinyl estradiol exposure when coadministered with oral contraceptives. In vivo studies demonstrated decreased exposure. Administer 4 hours prior to colesevelam.

Colesevelam Hydrochloride + Glibenclamide⚠️Major

Colesevelam may decrease sulfonylurea exposure. Administer glyburide 4 hours prior to colesevelam.

Colesevelam Hydrochloride + Glimepiride⚠️Major

Colesevelam may decrease sulfonylurea exposure. Administer glimepiride 4 hours prior to colesevelam.

Colesevelam Hydrochloride + Glipizide⚠️Major

Colesevelam may decrease sulfonylurea exposure. Administer glipizide 4 hours prior to colesevelam.

Colesevelam Hydrochloride + Levothyroxine⚠️Major

In vivo studies showed decreased levothyroxine exposure. Postmarketing reports of elevated TSH in patients on thyroid hormone replacement therapy.

Colesevelam Hydrochloride + Norethindrone⚠️Major

Colesevelam may decrease norethindrone exposure when coadministered with oral contraceptives. In vivo studies demonstrated decreased exposure. Administer 4 hours prior to colesevelam.

Colesevelam Hydrochloride + Olmesartan Medoxomil⚠️Major

Colesevelam may decrease olmesartan medoxomil exposure. Administer olmesartan medoxomil 4 hours prior to colesevelam.

Colesevelam Hydrochloride + Phenytoin⚠️Major

Postmarketing reports of increased seizure activity or decreased phenytoin levels in patients receiving phenytoin with colesevelam.

Colesevelam Hydrochloride + Warfarin⚠️Major

Postmarketing reports of reduced INR in patients receiving warfarin. Frequent INR monitoring required during initiation and periodically thereafter.

Colesevelam Hydrochloride + Amlodipine Besylate And Olmesartan Medoxomil🟡Moderate

Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose.

Colesevelam Hydrochloride + Metformin Extended Release🟡Moderate

WELCHOL may increase exposure of metformin extended release. Monitor patients' glycemic control.

Colesevelam Hydrochloride + Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide🟡Moderate

Reduces systemic exposure and peak plasma concentration of olmesartan. Administer olmesartan at least 4 hours before colesevelam hydrochloride.

Colesevelam Hydrochloride + Olmesartan Medoxomil And Amlodipine Besylate And Hydrochlorothiazide🟡Moderate

Reduces systemic exposure and peak plasma concentration of olmesartan. Administer olmesartan at least 4 hours before colesevelam hydrochloride.

Colesevelam Hydrochloride + Olmesartan Medoxomil And Hydrochlorothiazide🟡Moderate

May reduce absorption of olmesartan. Administer olmesartan at least 4 hours before colesevelam hydrochloride dose.

Colesevelam Hydrochloride + Olmesartan Medoxomil-Hydrochlorothiazide🟡Moderate

Reduces systemic exposure and peak plasma concentration of olmesartan. Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose.

Colesevelam Hydrochloride + Colesevelamℹ️Unknown

7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Administer these drugs 4 hours prior to colesevelam hydrochloride. Concomitant use with colesevelam hydrochloride may increase the exposure of the following drugs: Metformin extended release.

Colesevelam Hydrochloride + Olmesartanℹ️Unknown

7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Olmesartan Medoxomil Clinical Impact: In vivo drug interactions studies showed a decrease in olmesartan medoxomil when coadministered with colesevelam hydrochloride [see Clinical Pharmacology (12.3) ]. Intervention: Administer olmesartan medoxomil 4 hours prior to colesevelam hydrochloride.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.